does amlodipine cause post nasal drip

This can cause discomfort or a feeling that there is a lump in the throat. https://patient.info/forums/discuss/amlopidine-and-post-nasal-drip-257337. And you may feel worse after lying down for a while or after speaking for a long time. The sinuses drain down the back of the throat, and issues such as allergies, infections, and colds can make the process irritating or painful. How long does it take for amlodipine to work? Additional diagnostic tests used to determine the cause of postnasal drip may include: Contact your healthcare provider if you have signs of postnasal drip and/or any of the following symptoms: Postnasal drip can cause a chronic dry, sore throat with frequent coughing or throat clearing. Many individuals can treat their postnasal drip with home remedies, OTC nasal steroid sprays, or both. The GP also prescribed Rampiril and Aspirin ( 75 mg. ) daily. This list is not complete. Last medically reviewed on November 16, 2021. Along with its needed effects, a medicine may cause some unwanted effects. One of the most common causes of postnasal drip is allergies. I have since suffered a persistent dry cough, swollen ankles and the most horrendous abdominal cramps and stomach pain. Medically reviewed by Drugs.com. Postnasal drip is when mucus in your nose drains down the back of your throat. To stop post-nasal drip from waking you up, put an extra pillow under your head, which will help gravity usher down the drip while you snooze. Have been prescribed Amlopidine to treat high BP. It may lead to symptoms, such as a sore throat and trouble swallowing. Measures that allow mucus secretions to pass more easily may be recommended. Inhale steam. Amlodipine may cause serious side effects. Patient does not provide medical advice, diagnosis or treatment. Along with its needed effects, amlodipine / valsartan may cause some unwanted effects. Hong JY,Kim JH,Park S,Hwang YI,Jung KS,Jang SH. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any you start or stop using, especially: any other heart or blood pressure medications. allergic reactions to things like pollen, dust and pet fur. This causes the mucus to accumulate at the back of your throat. What medications cause swollen ankles and feet? amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide. The excess mucus can be caused by inflammation or swelling of the nasal passages, which can be due to a variety of factors such as viral or bacterial infections, headache, severe and throbbing. This lisinopril side effect drives many patients crazy because it can keep them awake at night, cause incontinence and make them miserable. If your postnasal drip symptoms recur every few days or weeks and resolve between episodes, then it could be related to an allergic reaction or sensitivity, such as to food. American Academy of Allergy Asthma & Immunology. Other side effects include: hypotension. Examples of these allergens include: Sinus infections, or sinusitis, are a common cause of postnasal drip. O 0. It rarely requires medical attention and often goes away on its own. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. If you have a fever, your postnasal drip may be caused by an infection. If you notice any other effects, check with your healthcare professional. Taste - Impaired in Contrave, how severe and when it was recovered? Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. If you are a Mayo Clinic patient, this could The Tongmenghui changed from a secret state what to do to lower your blood pressure to high blood pressure sinus medication which pressure meds nasal drip an open party. These particles can create problems in the body if they are not filtered out as a person breathes. Some side effects may not be reported. Antacids such as TUMS, Mylanta, and Gaviscon, or acid blockers such as Zantac or Pepcid also provide benefit. Some of these common symptoms include: sore throat. Talk to your doctor before starting any of these medications. Successful treatment of the post-nasal drip will usually clear up these throat symptoms. MNT is the registered trade mark of Healthline Media. Learn how to stay ENT healthy, prevent problems, and manage existing conditions to improve your, or a loved ones, daily life. Hi Louise ,my story with Lodi , Grommets , blocked Etruscan tube, polyps removed, dry mouth, keep drinking tea up to 15 cups a day, fair enough might be the other meds , i,m taking for BP, mucus in nose , flem back of throat , nasal spray , to help breathe, swollen ankles, , but just me i just might have found some thing that is helping D Ribose , I dont see anyone here mentioning Constipation , plus the need to pee all the time , how to cure the dry mouth & stop drinking tea that is causing me to pee . Weight gain with amlodipine may also be a symptom of edema, which is when you retain fluid, which may be particularly noticeable around your ankles or lower legs. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. The condition triggers a set of reactions that cause irritation and discomfort. Patient education: allergic rhinitis (beyond the basics), Swallowing problems increase risk of death, nursing home admissions, Patient education: nonallergic rhinitis (runny or stuffy nose. The glands in your nose and throat produce about 12 quarts of mucus per day. Other drugs that have the same active ingredients (e.g. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. 2004;17(6):343-5. doi:10.1016/j.pupt.2004.09.005, Sylvester DC, Karkos PD, Vaughan C, et al. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The use of the eHealthMe site and its content is at your own risk. The condition can make it difficult for the body to drain mucus correctly, causing postnasal drip. Continue reading for a comprehensive list of adverse effects. Postnasal drip occurs when your body produces too much mucus. Place this into a sinus bulb or syringe. We avoid using tertiary references. hearing loss. This content does not have an English version. Environmental triggers, such as allergies, cold weather, or dry air, may cause postnasal drip. Some potential causes of a runny nose include allergies, the common cold, and sinusitis. Amlodipine may cause serious side effects. Most people have experienced postnasal drip from time to time and know that it's usually nothing to worry about. The process of mucus draining down your throat usually occurs without your knowledge. Difficulty swallowing, trouble breathing, or a choking feeling. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Symptoms of GERD. Allergies are best managed by avoiding the causes. hyperventilation. With the chronic use of a medication, nasal obstruction can change over time and can be underestimated. Postnasal drip refers to excess mucus that someone may feel in the back of the nose and throat, causing a constant need to clear the throat. Verywell Health's content is for informational and educational purposes only. I take 10mg Amlodopine i probably should ask to change meds but as its working i just keep taking it. This may happen because your body produces more mucus than it needs or is not able to clear it as quickly as usual. 2012;2012:564852. doi:10.1155/2012/564852, Rennard BO, Ertl RF, Gossman GL, et al. Run a Humidifier at Night. All information is observation-only. By Anna Giorgi It is not known whether amlodipine will harm an unborn baby. You should also seek medical advice before starting home remedies if you're at an advanced age, take prescription medication or have an underlying health condition. Swallowing problems increase risk of death, nursing home admissions. Compared to nifedipine and other medications in the dihydropyridine class, amlodipine has the longest half-life at 30 to 50 hours. Surgery is a last resort to correct any structural issues in the sinuses that may be causing the symptoms. Among them, 5 people (0.0%) have Nasal discharge. I understand your dad has been experiencing post nasal drip and excessive mucus that is resistant to allergy medications and you wonder if it could be caused by his Although not all of these side effects may occur, if they do occur they may need medical attention. Having one or more of the following characteristics increases your risk of developing postnasal drip: Diagnosing postnasal drip usually begins with a complete physical examination, including medical history, to determine the cause of your symptoms. My primary said it was post nasal drip, asthma or heartburn. Using humidifiers or steam vaporizers may help relieve postnasal drip, especially in cases of clogged sinuses. Post-nasal drip syndromea symptom to be sniffed at? Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amlodipine only for the indication prescribed. Chicken soup inhibits neutrophil chemotaxis in vitro. Increasing the moisture in the air may help make postnasal drip thinner and allow it to move smoothly through the passageways. Try our Symptom Checker Got any other symptoms? No, postnasal drip is not in itself contagious. Patient education: nonallergic rhinitis (runny or stuffy nose. Smoke can also negatively impact the bodys ability to clear the airways. Is the ketogenic diet right for autoimmune conditions? In deciding to use a medicine, the risks of taking the medicine must be This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Learn more about these conditions. However, if the body produces too much or too thick mucus, it becomes much more apparent. Doctors call this postnasal drip. But if you seem to have postnasal drip frequently or for more than a few weeks, you should talk to your healthcare provider about it. Post-nasal drip is the medical term used to describe the dripping of mucus down the throat that can cause bad breath, throat irritation and constant coughing. Hope this is of some help. Diagnosing post-nasal drip may include a detailed ear, nose, and throat exam, endoscopy (using a camera to look inside the nose and throat), or X-rays. Postnasal drip generally lasts for a few days or weeks, depending on the cause. It occurs when stomach acid backs up into the esophagus. Along with its needed effects, amlodipine / valsartan may cause some unwanted effects. Do not drive if you think your driving ability is being compromised by metoprolol. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. It also covers causes, how they're treated, and when you should seek medical advice. This is especially important if you also take nitroglycerin. Drainage of Mucus Down the Back of Your Throat. Chest. This means it is not a good choice for lowering blood pressure quickly, and other agents, such as hydralazine, clonidine, and nifedipine XL (which work within 1 to 2 hours) are preferred. not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in Staying hydrated is an important part of treating postnasal drip. Antihistamines, decongestants, cromolyn and steroid nasal sprays, or oral steroids may offer relief. Sinusitis. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. A postnasal drip is excess mucus that the glands of the nose and throat secrete. Sniffles (Nasal Congestion and Discharge). Treatments for post-nasal drip. Summary. feeling of warmth. It is based on amlodipine besylate (the active ingredients of Amlodipine) and Amlodipine (the brand name). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. High blood pressure often has no symptoms. I did mention to the doctor that one of the side effects listed was rhinitis but they seemed to dismiss it. It triggers the overproduction of antibodies to protect you from perceived harm. International Foundation for Gastrointestinal Disorders. information is beneficial, we may combine your email and website usage information with Common symptoms of postnasal drip include: In addition to having more mucus, the quality of your mucus may change with postnasal drip. Bacterial infections are usually treated with antibiotics, nasal spray, decongestants, and nasal saline irrigations. Amlodipine has active ingredients of amlodipine besylate. All rights reserved. These side effects may go away during treatment as your body adjusts to the medicine. Try rinsing your nasal passageways with a. Injury and death to the developing fetus may result from drugs that act directly on the renin-angiotensin system. WebCauses of post-nasal drip can include: Bacterial infections; Allergies; Vasomotor rhinitis (overly sensitive nose) Medications that thicken mucus; Gastroesophageal reflux; Age; Postnasal drip is usually due to certain changes in the environment or the body. The discomfort that results can make it hard to get quality sleep, which can affect your health and well-being. Interventional tests may be necessary if GERD is a suspected cause. These include the below. In children, thick or foul-smelling secretions from one side of the nose can mean that something is stuck in the nose such as a bean, wadded paper, or piece of a toy. i have stopped the water tabs , typing this now have go get a drink tea .lol. American Academy of OtolaryngologyHead and Neck Surgery Foundation, Treating Acute Bacterial Rhinosinusitis (ABRS), World Sinus Health Awareness Day Resources, American Academy of OtolaryngologyHead and Neck Surgery Foundation, Feeling of mucus drainage into the throat, Vasomotor rhinitis (overly sensitive nose). UpToDate. eHealthMe is studying from 292,106 Amlodipine users for its effectiveness, alternative drugs and more. Another home remedy for postnasal drip involves thinning the mucus out. Why is drinking water important to relieve postnasal drip? You may report them to the FDA. Diet & lifestyle changes. This causes your body to produce extra mucus to eliminate the foreign substance. The study uses data from the FDA. Take the medicine at the same time each day. Drug information provided by: IBM Micromedex. nosebleeds. Get up slowly and steady yourself to prevent a fall. Can diet help improve depression symptoms? This was my first clue that amlodipine may be the culprit. Asthma and Allergy Foundation of America. American Academy of OtolaryngologyHead and Neck Surgery Foundation. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). It is best to treat postnasal drip early to avoid complications, so people should speak with a doctor for any symptoms lasting more than 10 days. Posted Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Also, mucus contains immune-system molecules, which can irritate the tissues and cause a sore throat, cough, and hoarseness. Higher humidity can help tamp down mucus and stop post-nasal drip. Cerner Multum, Inc. "UK Summary of Product Characteristics." Your blood pressure will need to be checked often. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Tell your doctor about all other heart or blood pressure medications you are taking. If these symptoms are observed, seek a physician for examination. Do not use this medicine in larger or smaller amounts or for longer than recommended. Kristin Hayes, RN, is a registered nurse specializing in ear, nose, and throat disorders for both adults and children. We comply with the HONcode standard for trustworthy health information. This process works to moisten and clear your nasal lining, and trap what is inhaled to protect your lungs from debris and infection. Amlodipine (also called Norvasc) is a medicine used to lower blood pressure and to relieve some types of chest pain. Amlodipine can pass into breast milk, but effects on the nursing baby are not known. If your child has these symptoms, seek immediate medical care. Painful infections may then develop. Enzalutamide, combined with standard treatment, shows promise in prostate cancer. While mucus itself isn't harmfulit helps protect you from illness and provides lubricationpostnasal drip can cause itchiness or a tickle in your throat, a cough, frequent throat clearing, and hoarseness. This is not a minor side effect. Lowering blood pressure helps prevent strokes, Don't know if the pills have changed as the packaging & I have been on Amlodipine for 2 years but about 3 months ago I developed symptoms of post nasal drip. Do not take extra medicine to make up the missed dose. Avoid using decongestants for more than three days at a time. However, individuals should note that some of these options may cause sedating effects. Common objects like a bean, coin, paper, or small toy can become lodged in the nostrils and interfere with normal breathing. ), Prasad S, Varshney S, Bist SS, Mishra S, Kabdwal N.Correlation study between nasal septal deviation and rhinosinusitis. Last updated on Feb 15, 2023. Many cases of postnasal drip clear up on their own. You will need a physical examination and imaging tests to look for any variations that could be causing your symptoms. Pain in my right knee completely disappeared with pain in my elbows and left knee lessening and not constant. Various drugs (including birth control pills and high blood pressure medications) and irregular nose cartilage can also produce increased mucus. Copyright 1996-2023 Cerner Multum, Inc. This mucus then drips down the back of your nose and gather in your throat. You should not take amlodipine if you are allergic to it. For example, treatments for hay fever include some prescription medications. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Your healthcare provider can determine the most appropriate treatment based on your age, medical history, current condition, and other symptoms. However, it becomes a problem when your body produces more mucus than it needs. This may also reduce the amount of mucus a person feels in their throat. 1650 Diagonal Road, Alexandria, VA 22314Tel 703-836-4444, Copyright 2023. However, if your postnasal drip persists despite treatment, you should consult your healthcare provider. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Research has suggested that taking your blood pressure medication at night instead of in the morning can provide better blood pressure control at night without compromising daytime blood pressure control and reduce your overall risk of dying because of cardiovascular disease by 45%. This condition causes an inflammation of the sinuses, which are air-filled cavities in the face. Generic name: amlodipine Many people, especially older persons. Seek emergency medical attention or call your doctor right away if you have symptoms such as: chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating. Anna Giorgi is a health and lifestyle writer who specializes in providing straightforward and accurate healthcare communications for consumers. If you have postnasal drip frequently, or always, it could be traced to an anatomical cause, such as a deviated septum. GERD diagnosis may include tests such as direct laryngoscopy (which uses a scope to examine the upper throat), 24-hour pH probe (which can test for acid reflux), or esophagogastroduodenoscopy (which looks at the lining of your esophagus, stomach, and small intestine). Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The most common adverse reactions were BUN increased greater than 50%, peripheral edema, nasopharyngitis, upper respiratory tract infection, and dizziness. Dry air irritates sinuses and can cause your body to ramp up mucus production. Nasal discharge (discharge from nose) is found to be associated with 848 drugs and 523 conditions by eHealthMe. Tylenol (acetaminophen) or cough lozenges for sore throat, Saline nasal spray to clear blocked nasal passages. You may report side effects to FDA at 1-800-FDA-1088. Possible causes range from allergies to acid reflux. This condition is often accompanied by a stuffy, runny nose, and itchy eyes. Morice AH. ENT specialists treat allergies, deviated septum, rhinitis, sinusitis, sinus headaches and migraines, nasal obstruction and surgery, and more. If you are more than 12 hours late, skip the missed dose. Hi there yes i suffer with postnasal drip and sinus problems. Tell your doctor if you are breast-feeding. Learn more here. of baking soda. You may report side effects to the FDA at 1-800-FDA-1088. These medications include: If you think your postnasal drip may be caused by a prescribed medication, contact your healthcare provider to discuss alternatives. By Kristin Hayes, RN The phase IV clinical study analyzes which people take Amlodipine and have Nasal discharge. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Nicole Leigh Aaronson, MD, MBA, CPE, FACS, FAAP, https://medlineplus.gov/druginfo/meds/a697014.html, https://medlineplus.gov/druginfo/meds/a618013.html, https://www.enthealth.org/conditions/deviated-septum/, https://www.enthealth.org/conditions/post-nasal-drip/, http://www.muschealth.org/ent/services/sinus-center/post-nasal-drip/index.html, https://www.sruk.co.uk/scleroderma/scleroderma-and-your-body/post-nasal-drip/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930664/, https://pubmed.ncbi.nlm.nih.gov/26731683/, Calorie restriction as effective as time-restricted eating in treating nonalcoholic fatty liver disease, Mediterranean and low-fat diets may be best at lowering risk of death, heart attacks, Depression: An amino acid may be key to improving treatment. The body loses water through postnasal drip. Harvard Health. UpToDate. Experts say any hot liquid will help thin mucus, which can help postnasal drip. Do not consume food and beverages for at least three hours before sleep. For example, the excess mucus can clog the Eustachian tubes, the canals that connect the throat to the middle ear, or the sinus passages. other information we have about you. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. There are several strategies for treating postnasal drip. Sinus infection (sinusitis). Continue reading, Amlodipine can take more than 8 hours to start working, because it takes a long time to be absorbed. This should help clear the mucus and cut down on your nausea. If you experience postnasal drip a few times per year, then there is probably nothing to worry about. * Approximation only. Kristin Hayes, RN, is a registered nurse specializing in ear, nose, and throat disorders for both adults and children. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Certain medications can cause or irritate nasal symptoms, which can lead to postnasal drip. Postnasal drip can make you uncomfortable during the day and restless at night. Seek emergency medical attention or call your doctor right away if you have symptoms such as: chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating. Call your doctor at once if you have: a light-headed feeling, like you might pass out. Common amlodipine side effects may include: the unsubscribe link in the e-mail. Mayo Clinic does not endorse companies or products. Many people can treat postnasal drip with home remedies, although sometimes, it is better to speak with a doctor for advice and treatment. Store at room temperature away from moisture, heat, and light. Thick secretions in winter often result from dryness in heated spaces. Overdose symptoms may include rapid heartbeats, redness or warmth in your arms or legs, or fainting. This position makes it easier for the acid to return to the esophagus and into the back of the throat. Purulent nasal secretions were observed in the nasal cavities of animals. Fatigue is a common side effect of 10 mg amlodipine besylate 1. Read our, How to Detect an Allergen and Remove It From Your Home, GERD and the Causes of Difficult Swallowing. Are There Tests to Diagnose Postnasal Drip? The symptoms can be irritating and include an itchy throat, coughing, hoarseness, and water eyes. Take amlodipine exactly as prescribed by your doctor. Other symptoms, such as a stiff neck, intense facial pressure, or trouble thinking or seeing, also require medical attention. Amlodipine is available as 2.5 mg tablet, The risk of edema is greater in women compared with men and in those people taking a higher dosage of amlodipine, and edema is usually noticed as weight gain. UpToDate. Having mucus in the back of your throat is normal. Do not change your doses or stop taking any of your medications without your doctor's advice. Food can affect absorption. Available for Android and iOS devices. Post-nasal drip can cause sore throat, cough, or throat clearing. Other drugs may interact with amlodipine, including prescription and over-the-counter medicines, vitamins, and herbal products. Are there any changes in my symptoms that I should be watching out for? It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor. Amlodipine is available under the following different brand names: Norvasc. [Ref], Very common (10% or more): BUN increased greater than 50% (up to 10.9%), Common (1% to 10%): Hypokalemia, serum potassium increased greater than 20%, Uncommon (0.1% to 1%): Anorexia, hypercalcemia, hyperlipidemia, hyperuricemia, hyponatremia, gout, non-insulin-dependent diabetes mellitus, hypercholesterolemia, Uncommon (0.1% to 1%): Weight increased, weight decreased, Very rare (less than 0.01%): Hyperglycemia, Frequency not reported: Serum potassium increased[Ref], Common (1% to 10%): Asthenia, fatigue, facial edema, edema, peripheral edema, pitting edema, Uncommon (0.1% to 1%): Ear pain, chest pain, pyrexia, Very common (10% or more): Peripheral edema (up to 10.3%), Common (1% to 10%): Fatigue, edema, ankle swelling, Uncommon (0.1% to 1%): Gynecomastia, asthenia, discomfort, malaise, non-cardiac chest pain, pain, Common (1% to 10%): Flushing, hot flush, orthostatic blood pressure decrease, Uncommon (0.1% to 1%): Palpitation, tachycardia, orthostatic hypotension, Common (1% to 10%): Palpitation, flushing, Very rare (less than 0.01%): Arrhythmia, myocardial infarction, vasculitis, Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection, Uncommon (0.1% to 1%): Cough, pharyngolaryngeal pain, sinusitis, bronchitis, pharyngitis, pharyngotonsillitis, bronchitis acute, tonsillitis, sinus congestion, dyspnea, epistaxis, productive cough, dysphonia, nasal congestion, Uncommon (0.1% to 1%): Coordination abnormal, dizziness postural, paresthesia, somnolence, vertigo, sciatica, cervicobrachial syndrome, carpal tunnel syndrome, hypoesthesia, sinus headache, Common (1% to 10%): Dizziness, headache, somnolence, Uncommon (0.1% to 1%): Dysgeusia, paresthesia, syncope, tremor, hypoesthesia, tinnitus, Very rare (less than 0.01%): Hypertonia, peripheral neuropathy, neuropathy, Frequency not reported: Extrapyramidal syndrome, Common (1% to 10%): Creatine kinase increased greater than 300%, Uncommon (0.1% to 1%): Arthralgia, back pain, joint swelling, epicondylitis, joint sprain, limb injury, muscle spasm, pain in extremity, myalgia, osteoarthritis, musculoskeletal chest pain, Rare (less than 0.1%): Sensation of heaviness, Uncommon (0.1% to 1%): Arthralgia, back pain, muscle spasm, myalgia, Postmarketing reports: Rhabdomyolysis[Ref], Very rare (less than 0.01%): Hypersensitivity, Frequency not reported: Hypersensitivity[Ref], Common (1% to 10%): Creatinine increased greater than 50%, Frequency not reported: Serum creatinine increased, renal failure and impairment[Ref], Common (1% to 10%): ALT increased greater than 150%, Very rare (less than 0.01%): Liver function test abnormal, serum bilirubin increased, hepatitis, intrahepatic cholestasis, jaundice, Frequency not reported: Liver function test abnormal, serum bilirubin increased[Ref], Uncommon (0.1% to 1%): Abdominal discomfort, abdominal distention, abdominal pain, upper abdominal pain, constipation, diarrhea, dry mouth, nausea, dyspepsia, gastritis, vomiting, colitis, gastroenteritis, Common (1% to 10%): Abdominal discomfort, upper abdominal pain, nausea, Uncommon (0.1% to 1%): Change of bowel habit, diarrhea, dry mouth, dyspepsia, vomiting, Very rare (less than 0.01%): Gastritis, gingival hyperplasia, pancreatitis, Uncommon (0.1% to 1%): Abdominal discomfort, upper abdominal pain[Ref], Uncommon (0.1% to 1%): Erythema, rash, pruritus, hyperhidrosis, eczema, Uncommon (0.1% to 1%): Alopecia, exanthema, hyperhidrosis, photosensitivity reaction, pruritus, purpura, rash, skin discoloration, Very rare (less than 0.01%): Angioedema, erythema multiforme, urticaria, exfoliative dermatitis, Stevens-Johnson syndrome, Quincke edema, Frequency not reported: Angioedema, dermatitis bullous, pruritus, rash[Ref], Uncommon (0.1% to 1%): Hematuria, pollakiuria, erectile dysfunction, Uncommon (0.1% to 1%): Micturition disorder, nocturia, pollakiuria, impotence[Ref], Uncommon (0.1% to 1%): Insomnia, anxiety, depression, Uncommon (0.1% to 1%): Depression, insomnia/sleep disorders, mood swings, Rare (less than 0.1%): Visual disturbance, Uncommon (0.1% to 1%): Visual disturbance, visual impairment[Ref], Very rare (less than 0.01%): Leukopenia, thrombocytopenia, Frequency not reported: Hemoglobin decreased, hematocrit decreased, neutropenia, thrombocytopenia[Ref], 1.

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