foods to avoid with comt mutation

Exercise is important for good health. To provide the best experiences, we use technologies like cookies to store and/or access device information. 4. Work with your doctor. And if you arent aware of the issue, then you may experience long periods of ill health without any obvious cause. Sparta M, Alexandrova AN. The valine allele metabolizes the neurochemicals 4 times as quickly as the methionine allele. We make no claims that specific nutrition, therapies, diet, or other health-related decisions will cure or mediate any disease or sickness; this includes cancer, lyme disease, autoimmune conditions, or Sars-CoV-2 (COVID-19). WebAnswer (1 of 4): That will depend on what the mutation is. The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network. Your genetic variants could be causing you to be more sensitive to foods high in histamine. You alone are solely and personally responsible for the results, and your success depends primarily on your own effort, motivation, commitment, and follow-through. Symptoms of increased gene expression (and therefore a decrease in the neurotransmitters) may include: (remember, OTHER issues can cause these same symptoms (like a Histamine intolerance) which is COMPLETELY unrelated!). Other natural substances/choices to help increase Serotonin and Dopamine levels (SLOW MAO pathway) if you have an UP-regulated gene pathway: Thats okay, were here to guide you on your journey. Ho PW, Tse ZH, Liu HF, et al. You obviously cant change your genes, so you cant eliminate a COMT mutation. Both the G and A allele ofG472A in the COMT gene are associated withneurologicalcharacteristics associated with altered COMT activity 4. Systems pharmacogenomics gene, disease, drug and placebo interactions: A case study in COMT. Monoamine oxidase (MAO) converts both metanephrines to VMA. Can you handle it, or do you get angry and anxious when things get too fast? Work with your doctor. Releasing stress hormones is a quick way to overload an already slow COMT gene. The foods that we eat contain a vast number of separate chemical entities: several thousand as additives and many times this number as natural constituents. You can find all the references for this post organized at the bottom of this piece. This means you might experience higher than usual levels of these chemicals as well as the metabolites they help create. Low levels, on the other hand, are associated with: This mutation also slows down the processing and expulsion of NTs and other related chemicals, which can make issues related to the processing of these chemicals worse than normal. COMT gene mutations symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced. While many practitioners adjust dose, add methylcobalamin, or various amino acids, I wanted to go deeper into the genetic pathology. Assessment of Cellular Estrogenic Activity Based on Estrogen Receptor-Mediated Reduction of Soluble-Form Catechol-O-Methyltransferase (COMT) Expression in an ELISA-Based System. Copyright 2020 Michael Lam, M.D. High protein foods that contain the amino acids tryptophan, tyrosine, or phenylalanine, as these can trigger a release of catechol and be converted into dopamine in the body. Malloy-Diniz LF, Lage GM, Campos SB, et al. Adopting strategies to lower your stress levels will decrease your bodys demand for cortisol and lower adrenal activity. By you using this site, you agree the information contained here is for informational purposes only. Yeter D, Deth R, Kuo HC. While animal and cell studies show EGCG to be an inhibitor of COMT, studies in humans arent as clear. Dr. Gina Leisching holds a BSc in Functional Human Biology, and Honours degree in Physiological Sciences, as well as a doctorate in human physiology from Stellenbosch University, South Africa. Catechols include neurotransmitters such as dopamine, epinephrine, and norepinephrine. MAO inhibitors (EX: Cymbalta, Wellbutrin) are a class of medications commonly prescribed to people with depression. Taking magnesium can support the bodys ability to have a healthy stress response as it enables the COMT gene to clear stress from the body. The COMT enzyme formed from the minor A allele has been reported as having approximately a 75% reduction in activity compared to those formed from the major G allele 5. https://doi.org/10.3390/nu12082336 This includes COMT gene testing as well as MTHFR, MTRR, CBS, SOD2, VDR, PEMT, and many more. Slow COMT activity may mean that you dont have enough SAMe or too much homocysteine. Branched chain amino acids selectively promote cardiac growth at the end of the awake period. These NTs are responsible for planning, behavioral inhibitions, short-term memory, and stress reactions. Quercetin increased the antiproliferative activity of green tea polyphenol ()-epigallocatechin gallate in prostate cancer cells. To learn more about the COMT gene with in-depth health questionnaires, I highly recommend reading Dirty Genes by Dr. Ben Lynch. Methionine is typically formed by the processing of homocysteine using either methionine synthase (MTR) orbetaine homocysteine methyltransferase (BHMT). (2014). Nutritional coaching has its limitations and is not for everyone and there is no guarantee of acceptance into the program. * Dr. Lam in our products and services refers to Dr. Michael P. Lam, MD, founder of DrLam.com and DrLamCoaching.com. Save my name, email, and website in this browser for the next time I comment. Along with MTR and BHMT there is an alternative pathway to clear homocysteine using cystathionine synthase (CBS) and cystathionine ligase (CTH). The Val158Met polymorphism in COMT gene and cancer risk: Role of endogenous and exogenous catechols. COMT plays an important role in inactivating several neurotransmitters including: Inactivation of these neurotransmitters is important to ensure that the amount that binds to their receptors remain constant and at physiologically normal levels. WebBalancing COMT & MAO Pathway Variant issues. If youre one of the many people with this type of gene mutation, then heres what to do: If youre concerned about how your body reacts to stress, our team at Dr. Lam offers a free consultation at (626) 571 1234, or you can access our Ask the Doctor system by clicking here. Our natural alternative is magnesium, well-known for its calming activity. https://doi.org/10.1016/j.taap.2010.06.011 Someone with a dirty slow COMT gene is likely to feel anxious and moody. [ref] While apples are high in quercetin, it would take a ton of apples to reach the levels of quercetin that are used in studies to inhibit COMT. For some people, low-dose, supplemental lithium orotate is a game-changer for mood issues when combined with vitamin B12. There are lots of factors that can influence how your body reacts to stress, including a COMT mutation. Thank you, Dr Ben Lynch. (2015). COMT plays an important role in inactivating several neurotransmitters including: Dopamine; Epinephrine; Norepinephrine 2. Certain types of phytonutrients should be avoided as they contain catechols and will impact your COMT mutation. Check your genetic data to see if this could be at the root of your symptoms. Copious research has been conducted demonstrating associations of COMT variants with different conditions. Related article: Deep dive into COMT and studies on mood, cognitive function, and more. And some sites go so far as to give smiley faces or frowny faces. The COMT gene helps make an essential enzyme known as catechol-O-methyltransferase. Miller, R. J., Jackson, K. G., Dadd, T., Nicol, B., Dick, J. L., Mayes, A. E., Brown, A. L., & Minihane, A. M. (2012). In people with a COMT mutation, their body finds it challenging to remove catechols. Similarly the T allele of C186T is always present when the A allele of G472A is. Funny enough, my husbands grandfather made the paper once with his eggplants nose, and out of the weird mutant vegetables, this one is the most funny to me. If your COMT is too slow, your stress neurotransmitters stay in your body longer, causing you to feel wired and anxious. While apples are high in quercetin, it would take a ton of apples to reach the levels of quercetin that are used in studies to inhibit COMT. Talk to your doctor and get tested for this mutation. Your liver is essential for deactivating and expelling metabolites, so you need to keep it healthy. Systems pharmacogenomics gene, disease, drug and placebo interactions: A case study in COMT. The foods that we eat contain a vast number of separate chemical entities: several thousand as additives and many times this number as natural constituents. This can result in ongoing activation of the NEM stress response. Avoid/limit foods high in tyrosine, tryptophan, phenylalanine and other amines since these amino acids are precursors in the pathway: Green Coffee bean extract (in diet supplements). But, if youre like many people in the modern world, then youre under chronic stress because of lifestyle and environmental factors. Usually, your NeuroEndoMetabolic (NEM) Stress Response does its work behind the scenes to help you cope with stress, and then it shuts down once your stress levels go down again. Alcohol, since it can trigger a dopamine release in your body. Hugs raise dopamine levels. Thats why its important that you practice stress reduction strategies regularly and do everything you can to support your body in its fight against stress and the damage it can do. Depending on your gene copy number, you could be classed as a: This variant confers resilience to stress as well as an emotional advantage over individuals with the AG (worrier) genotype. These can be found in foods like onions, parsley, celery, chamomile, and grapefruit. Drug Metabolism Reviews, 49(1), 5683. Ghosh P, Sarkar K, Bhaduri N, et al. As opposed to MTR and BHMT which form methionine, CBS and CTH form cysteine, and so should not be limited by methionine accumulation. It is vital that you include healthy eating, good sleep, movement and avoid excessive environmental toxins. Foods to avoid with slow COMT genes and how to support a slow COMT Catechin-containing foods and drinks such as chocolate, wine, coffee, and green tea are metabolized via the COMT gene, and these foods are best avoided if you have a slow COMT. The main responsibility of these genes is to degrade neurotransmitters and get rid of them to keep proper balance. It may also have an important role in AFS and in your recovery from it. Scientific Reports, 5, 8813. https://doi.org/10.1038/srep08813 So its important to eliminate anything that will increase catechol levels in your body such as: When you have excess estrogen in your body, it slows COMT processes. Chocolate. The function of the COMT gene is to help metabolize estrogen, dopamine, norepinephrine, and epinephrine. Hall, K. T., Loscalzo, J., & Kaptchuk, T. J. ~ Read Member's Only sections. Genetic variants in the inflammatory-related genes can increase the risk of depression and anxiety. The variant results from a methionine molecule replacing a valine molecule at this position on the gene. Elevated beta-glucuronidase activity and thus, high estrogen levels are associated with an increased risk of hormone dependent cancers such as breast cancer, prostate cancers, and colon cancers. The unnatural level of activity causes the individual components to degrade in health, affecting the circuit overall. Addressing complete lifestyle changes is of UTMOST importance! A multitude of treatments, from pharmaceutical COMT inhibitors (tolcapone, entacapone), to green tea and epigallocatechin gallate (ECGC), can inhibit COMT activity, thereby elevating catecholamines. Eggs. However, you still need to stay healthy overall and limit oxidative damage in your body by eating a healthy balance of plant nutrients. American Journal of Human Genetics, 75(5), 807821. The COMT valine polymorphism (associated with lower dopamine and lower cognitive function) has been associated with apathy and depression.7 In this case, the lower dopamine is caused by high metabolism, not low production. Avoid high phosphorus foods like coffee, black tea, green tea, all sodas including seltzer and sparkling water, legumes (beans peas lentils peanuts, soy and soy sauce) Avoid yams, they too are high in phosphorus. This field is for validation purposes and should be left unchanged. More difficult is finding a COMT activator. Magnesium is an essential mineral needed to make SAMe as well. In people with a COMT mutation, their body finds it challenging to remove catechols. You should not use this information to diagnose or treat a health problem without consulting a qualified healthcare provider. Its also an essential part of your ability to recover from stress. Glutathione The second thing that happens is that the six circuits that make up the NEM stress response start to become unbalanced when your NEM stress response is active for too long. At what amounts do you need to think about these interactions? When they stopped their supplementation, the side effects resolved. The function of the COMT enzyme is to help metabolize estrogen, dopamine, norepinephrine, and epinephrine. However, theres a point at which she cant get rid of the chocolates as fast as theyre being made. Its actually quite simple to test for COMT and MTHFR gene mutations. So, how do you know if your patients have a COMT enzyme malfunction? The use of any information provided on this web site is solely at your own risk. A multitude of treatments, from pharmaceutical COMT inhibitors (tolcapone, entacapone), to green tea and epigallocatechin gallate (ECGC), can inhibit COMT activity, thereby elevating catecholamines. The imbalances that occur with AFS will only worsen this situation. While apples are high in quercetin, it would take a ton of apples to reach the levels of quercetin that are used in studies to inhibit COMT. COMT inhibitors are used to increase dopamine levels in people who are taking levodopa. Eat healthy protein with amino acids at meals and avoid sugar and refined carbohydrates. https://doi.org/10.1016/j.yjmcc.2021.04.005 Everyones adrenals have different tolerance levels for this kind of overwork, but when you hit your individual limit, your adrenals will start to malfunction and eventually degrade. Hall, K. T., Buring, J. E., Mukamal, K. J., Vinayaga Moorthy, M., Wayne, P. M., Kaptchuk, T. J., Battinelli, E. M., Ridker, P. M., Sesso, H. D., Weinstein, S. J., Albanes, D., Cook, N. R., & Chasman, D. I. Get lots of hugs! Someone with a fast COMT gene metabolizes dopamine faster. Please be advised that the coaches and other staff members at Conners Clinic are NOT licensed to practice medicine in Minnesota; DO NOT practice medicine; DO NOT prescribe, give, or administer any drug or medicine; DO NOT offer or undertake to prevent, diagnose, correct, or treat any disease, illness, pain, wound, fracture, infirmity, deformity or defect; and DO NOT offer to undertake to perform any form of surgery or hypnosis. Causing additional strain in the service of trying to improve your health will only delay or derail your recovery. Pathways may be likened to highways that can be flowing smoothly at times with no traffic delays. The body requires B vitamins, magnesium, and a well-functioning methylation pathway to make the methyl donor SAMe. Wang, L.-J., Lee, S.-Y., Chen, S.-L., Chang, Y.-H., Chen, P. S., Huang, S.-Y., Tzeng, N.-S., Chen, K. C., Lee, I. H., Wang, T.-Y., Yang, Y. K., & Lu, R.-B. This enzyme helps to degrade catecholamines like dopamine, norepinephrine, and epinephrine as well as drugs and substances that have the same catechol structure. A step by step guide is available on the Advanced Functional Medicine website to easily arrange your genome test. Potatoes (all, even sweet potatoes) Coffee. Neuroinflammation and neurodegeneration: The promising protective role of the citrus flavanone hesperetin. Jared M. Skowron, ND, is the Amazon best-selling author of the books, 100 Natural Remedies For Your Child and Fundamentals of Naturopathic Pediatrics. The most common variant in this context was found to be defined by an amino acid substitution of methionine (Met) in place of valine (Val) at position 158 (Val158Met). High protein foods that contain the amino acids tryptophan, tyrosine, or phenylalanine, as these can trigger a release of catechol and be converted into dopamine in the body. Oxalic acid depletes B6. Scenario #2) In Parkinsons disease, there is not enough dopamine in certain regions of the brain. https://doi.org/10.1016/j.fct.2019.03.049 Gelatin. COMT mutations have been associated with both ADHD1 and autism.2 Children carrying the methionine allele (associated with higher dopamine) show better performance in numerical tasks such as magnitude assessment, while children who are homozygous for the COMT valine allele (associated with lower dopamine) have slower processing in this area.3 The methionine allele has been associated with impulsiveness and poor decision-making.4 Individuals carrying The Val158Met polymorphism in COMT gene and cancer risk: Role of endogenous and exogenous catechols. Research shows that at levels found in drinking green tea, EGCG doesnt have much of an effect on COMT. High estrogen levels due to a slow COMT gene can cause symptoms such as PMS, fibroids, breast tenderness, irregular menstrual periods, and mood swings. Theoretically, treatment with methylfolate would have the same effect. This information is not intended as a substitute for the advice provided by your physician or other healthcare professional.

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